Topical Administration of Lactiplantibacillus plantarum (SkinDuo^TM) Serum Improves Anti-Acne Properties.

ABSTRACT: The tailoring of the skin microbiome is challenging and is a research hotspot in the pathogenesis of immune-mediated inflammatory skin diseases such as acne. Commonly encountered preservatives used as functional ingredients have an impact on the skin microbiota and are known to inhibit the survival of skin commensal bacteria. The selected species is Lactiplantibacillus plantarum, formulated with natural enhancers for topical use (SkinDuo^TM). Ex vivo human skin models were used as a test system to assess the strain viability which was then validated on healthy volunteers. SkinDuo^TM showed increased viability over time for in vitro skin models and a stable viability of over 50% on healthy skin. The strain was tested on human primary sebocytes obtained from sebace

SUBMITTER: Podrini C 

PROVIDER: S-EPMC9967017 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature