The Role of Tight Junctions in Atopic Dermatitis: A Systematic Review.

ABSTRACT:

Background

Tight junctions are transmembrane proteins that regulate the permeability of water, solutes including ions, and water-soluble molecules. The objective of this systematic review is to focus on the current knowledge regarding the role of tight junctions in atopic dermatitis and the possible impact on their therapeutic potential.

Methods

A literature search was performed in PubMed, Google Scholar, and Cochrane library between 2009 and 2022. After evaluation of the literature and taking into consideration their content, 55 articles were finally included.

Results

TJs' role in atopic dermatitis extends from a microscopic scale to having macroscopic effects, such as increased susceptibility to pathogens and infections and worsening of atopic dermatitis features. I

SUBMITTER: Katsarou S 

PROVIDER: S-EPMC9967084 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature