TG-DSC and TG-FTIR Studies of Annelated Triazinylacetic Acid Ethyl Esters-Potential Anticancer Agents.

ABSTRACT: To avoid problems associated with the storage and processing of newly developed potential medicines, there is a need to carry out thermal studies in the preclinical phase of drug development. The thermal behaviour and decomposition pathway of a whole novel class of patented potential molecular pharmaceutics, i.e., ethyl 2-[4-oxo-8-(R-phenyl)-4,6,7,8-tetrahydroimidazo[2,1-c][1,2,4]triazin-3-yl]acetates (1-6) were reported for the first time in inert and oxidative atmospheres. The experiments were conducted with the use of simultaneous thermogravimetry/differential scanning calorimetry (TG-DSC) and simultaneous thermogravimetry coupled with Fourier transform infrared spectroscopy (TG-FTIR). The decomposition pathways of compounds 1-6 were found to be differ

SUBMITTER: Ostasz A 

PROVIDER: S-EPMC9967103 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature