Untargeted Metabolomics Based Prediction of Therapeutic Potential for Apigenin and Chrysin.

ABSTRACT: The prominent flavonoids apigenin and chrysin have been demonstrated to have systemic benefits. Our previous work was first to establish the impact of apigenin and chrysin on cellular transcriptome. In the current study, we have revealed the ability of apigenin and chrysin to alter the cellular metabolome based on our untargeted metabolomics. Based on our metabolomics data, both these structurally related flavonoids demonstrate diverging and converging properties. Apigenin demonstrated the potential to possess anti-inflammatory and vasorelaxant properties through the upregulation of intermediate metabolites of alpha-linolenic acid and linoleic acid pathways. Chrysin, on the other hand, exhibited abilities to inhibit protein and pyrimidine synthesis along with downregulation of gluconeogene

SUBMITTER: Cochran C 

PROVIDER: S-EPMC9967419 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature