Synthetic Cinnamides and Cinnamates: Antimicrobial Activity, Mechanism of Action, and In Silico Study.

ABSTRACT: The severity of infectious diseases associated with the resistance of microorganisms to drugs highlights the importance of investigating bioactive compounds with antimicrobial potential. Therefore, nineteen synthetic cinnamides and cinnamates having a cinnamoyl nucleus were prepared and submitted for the evaluation of antimicrobial activity against pathogenic fungi and bacteria in this study. To determine the minimum inhibitory concentration (MIC) of the compounds, possible mechanisms of antifungal action, and synergistic effects, microdilution testing in broth was used. The structures of the synthesized products were characterized with FTIR spectroscopy, ¹ H-NMR, ¹³ C-NMR, and HRMS. Derivative 6 presented the best antifungal profile, suggesting that the presen

SUBMITTER: de Morais MC 

PROVIDER: S-EPMC9967511 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature