Magnetic Field Dependence of Spectral Correlations between ³¹P-Containing Metabolites in Brain.

ABSTRACT: Spectral correlations between metabolites in ³¹P magnetic resonance spectroscopy (MRS) spectra of human brain were compared at 3 and 7 Tesla, the two commonly used magnetic field strengths for clinical research. It was found that at both field strengths, there are significant correlations between ³¹P-containing metabolites arising from spectral overlap, and their downfield correlations are markedly altered by the background spectral baseline. Overall, the spectral correlations between ³¹P-containing metabolites are markedly reduced at 7 Tesla with the increased chemical shift dispersion and the decreased membrane phospholipid signal. The findings provide the quantitative landscape of pre-existing correlations in ³¹P MRS spectra due to overlapping

SUBMITTER: Hong S 

PROVIDER: S-EPMC9967573 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature