Influence of the Fatty Acid Metabolism on the Mode of Action of a Cisplatin(IV) Complex with Phenylbutyrate as Axial Ligands.

ABSTRACT: For a variety of cancer types, platinum compounds are still among the best treatment options. However, their application is limited by side effects and drug resistance. Consequently, multi-targeted platinum(IV) prodrugs that target specific traits of the malignant tissue are interesting new candidates. Recently, cisPt(PhB)₂ was synthesized which, upon reduction in the malignant tissue, releases phenylbutyrate (PhB), a metabolically active fatty acid analog, in addition to cisplatin. In this study, we in-depth investigated the anticancer properties of this new complex in cell culture and in mouse allograft experiments. CisPt(PhB)₂ showed a distinctly improved anticancer activity compared to cisplatin as well as to PhB alone and was able to overcome various frequently o

SUBMITTER: Mendrina T 

PROVIDER: S-EPMC9967619 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature