Targeting Epigenetic Changes Mediated by Members of the SMYD Family of Lysine Methyltransferases.

ABSTRACT: A comprehensive understanding of the mechanisms involved in epigenetic changes in gene expression is essential to the clinical management of diseases linked to the SMYD family of lysine methyltransferases. The five known SMYD enzymes catalyze the transfer of donor methyl groups from S-adenosylmethionine (SAM) to specific lysines on histones and non-histone substrates. SMYDs family members have distinct tissue distributions and tissue-specific functions, including regulation of development, cell differentiation, and embryogenesis. Diseases associated with SMYDs include the repressed transcription of SMYD1 genes needed for the formation of ion channels in the heart leading to heart failure, SMYD2 overexpression in esophageal squamous cell carcinoma (ESCC) or p53-related cancers, and poor pro

SUBMITTER: Padilla A 

PROVIDER: S-EPMC9967872 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature