Ischemic Stroke Causes Disruptions in the Carnitine Shuttle System.

ABSTRACT: Gaining a deep understanding of the molecular mechanisms underlying ischemic stroke is necessary to develop treatment alternatives. Ischemic stroke is known to cause a cellular energy imbalance when glucose supply is deprived, enhancing the role for energy production via β-oxidation where acylcarnitines are essential for the transportation of fatty acids into the mitochondria. Although traditional bulk analysis methods enable sensitive detection of acylcarnitines, they do not provide information on their abundances in various tissue regions. However, with quantitative mass spectrometry imaging the detected concentrations and spatial distributions of endogenous molecules can be readily obtained in an unbiased way. Here, we use pneumatically assisted nanospray desorption electrospray ionizat

SUBMITTER: Mavroudakis L 

PROVIDER: S-EPMC9968086 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature