Alginate Ag/AgCl Nanoparticles Composite Films for Wound Dressings with Antibiofilm and Antimicrobial Activities.

ABSTRACT: Recently, silver-based nanoparticles have been proposed as components of wound dressings due to their antimicrobial activity. Unfortunately, they are cytotoxic for keratinocytes and fibroblasts, and this limits their use. Less consideration has been given to the use of AgCl nanoparticles in wound dressings. In this paper, a sustainable preparation of alginate AgCl nanoparticles composite films by simultaneous alginate gelation and AgCl nanoparticle formation in the presence of CaCl₂ solution is proposed with the aim of obtaining films with antimicrobial and antibiofilm activities and low cytotoxicity. First, AgNO₃ alginate films were prepared, and then, gelation and nanoparticle formation were induced by film immersion in CaCl₂ solution. Films characterizat

SUBMITTER: Puccetti M 

PROVIDER: S-EPMC9968148 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature