Phosphatidylcholine Liposomes Reprogram Macrophages toward an Inflammatory Phenotype.

ABSTRACT: Phospholipids are the major components of cellular membranes and cell-derived vesicles such as exosomes. They are also key components of artificial lipid nanoparticles, allowing the encapsulation and transport of various biological or chemical cargos. Both artificial and natural vesicles could be captured by cells delivering important information that could modulate cellular functions. However, the potential contribution of phospholipids within vesicles altering cellular physiology has been largely underestimated. Here, we showed that macrophages exposed to liposomes made exclusively with palmitoyl oleoyl phosphatidylcholine (POPC) in vivo resulted in a dramatic alteration of the transcriptome profile. Differential gene expression analysis indicated that the exposure to POPC liposomes resu

SUBMITTER: Cauvi DM 

PROVIDER: S-EPMC9968183 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature