Bright Tm³⁺-based downshifting luminescence nanoprobe operating around 1800 nm for NIR-IIb and c bioimaging.

ABSTRACT: Fluorescence bioimaging based on rare-earth-doped nanocrystals (RENCs) in the shortwave infrared (SWIR, 1000-3000 nm) region has aroused intense interest due to deeper penetration depth and clarity. However, their downshifting emission rarely shows sufficient brightness beyond 1600 nm, especially in NIR-IIc. Here, we present a class of thulium (Tm) self-sensitized RENC fluorescence probes that exhibit bright downshifting luminescence at 1600-2100 nm (NIR-IIb/c) for in vivo bioimaging. An inert shell coating minimizes surface quenching and combines strong cross-relaxation, allowing LiTmF₄@LiYF₄ NPs to emit these intense downshifting emissions by absorbing NIR photons at 800 nm (large Stokes shift ~1000 nm with a absolute quantum yield of ~14.16%) or 1208 nm (NIR-II

SUBMITTER: Chang Y 

PROVIDER: S-EPMC9968279 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature