Resting-state brain functional alterations and their genetic mechanisms in drug-naive first-episode psychosis.

ABSTRACT: Extensive research has established the presence of resting-state brain functional damage in psychosis. However, the genetic mechanisms of such disease phenotype are yet to be unveiled. We investigated resting-state brain functional alterations in patients with drug-naive first-episode psychosis (DFP) by performing a neuroimaging meta-analysis of 8 original studies comprising 500 patients and 469 controls. Combined with the Allen Human Brain Atlas, we further conducted transcriptome-neuroimaging spatial correlations to identify genes whose expression levels were linked to brain functional alterations in DFP, followed by a range of gene functional characteristic analyses. Meta-analysis revealed a mixture of increased and decreased brain function in widespread areas including the default-mode

SUBMITTER: Li Q 

PROVIDER: S-EPMC9968350 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature