High Expression of G9a Induces Cisplatin Resistance in Hepatocellular Carcinoma.

ABSTRACT:

Objective

Chemotherapeutic drug resistance is the main obstacle that affects the efficacy of current therapies of hepatocellular carcinoma (HCC), which needs to be addressed urgently. High expression of histone methyltransferase G9a was reported to play a pivotal role in the progression of HCC. Regulatory mechanism of aberrant activation of G9a in HCC and the association with subsequent cisplatin (DDP) resistance still remains ambiguous. This study strived to investigate mechanism of G9a overexpression and its impact on cisplatin resistance in HCC cells.

Materials and methods

In this experimental study, we investigated effects of different concentrations of cisplatin in combination with BIX-01294 or PR-619 on viability and apoptosis of HuH7 and SNU387 cells via CCK-8 kit and

SUBMITTER: Fu J 

PROVIDER: S-EPMC9968374 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature