Transforming growth factor receptor III (Betaglycan) regulates the generation of pathogenic Th17 cells in EAE.

ABSTRACT: The transforming growth factor receptor III (TβRIII) is commonly recognized as a co-receptor that promotes the binding of TGFβ family ligands to type I and type II receptors. Within the immune system, TβRIII regulates T cell development in the thymus and is differentially expressed through activation; however, its function in mature T cells is unclear. To begin addressing this question, we developed a conditional knock-out mouse with restricted TβRIII deletion in mature T cells, necessary because genomic deletion of TβRIII results in perinatal mortality. We determined that TβRIII null mice developed more severe autoimmune central nervous neuroinflammatory disease after immunization with myelin oligodendrocyte peptide (MOG_35-55) than wild-type littermates. The increase in disease

SUBMITTER: Duesman SJ 

PROVIDER: S-EPMC9968395 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature