Novel Therapeutic Approaches to Invasive Candidiasis: Considerations for the Clinician.

ABSTRACT: Invasive candidiasis (IC), due to the yeast pathogen Candida, is still a major cause of in-hospital morbidity and mortality. The limited number of antifungal drug classes and the emergence of multi-resistant Candida species, such as Candida auris and some Candida glabrata isolates, is concerning. However, recent advances in antifungal drug development provide promising perspectives for the therapeutic approach of IC. Notably, three novel antifungal agents, currently in Phase II/III clinical trials, are expected to have an important place for the treatment of IC in the future. Rezafungin is a novel echinocandin with prolonged half-life. Ibrexafungerp and fosmanogepix are two first-in-class antifungal drugs with broad spectrum activity against Candida spp.,

SUBMITTER: Lamoth F 

PROVIDER: S-EPMC9968438 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature