Adjuvant chemotherapy in node-positive patients after esophagectomy for esophageal squamous cell carcinoma.

ABSTRACT:

Background

The role of adjuvant chemotherapy in esophageal squamous cell carcinoma (ESCC) remains controversial. This study aimed to evaluate the impact of adjuvant chemotherapy on survival in patients with positive nodes after surgery for ESCC.

Methods

We retrospectively reviewed the survival outcomes of node-positive patients with ESCC who underwent curative resection with or without adjuvant chemotherapy between January 1994 and December 2015.

Results

We analyzed 460 patients (333 adjuvant chemotherapy, 127 surgery alone). The surgery-alone group was older (64 vs. 60 years, p < 0.001) and had more comorbidities (p = 0.004) than the adjuvant chemotherapy group. After propensity score matching, overall survival (OS) and recurrence-free survival (RFS) of the adjuvant

SUBMITTER: Jeon YJ 

PROVIDER: S-EPMC9968597 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature