Comparison of humoral response in kidney transplant recipients and donors and healthy volunteers following second dose of SARS-CoV-2 mRNA vaccine

ABSTRACT:

Purpose

: To investigate the kinetics and durability of anti-spike glycoprotein (S) immunoglobulin G (IgG) following the 2nd dose of mRNA-based severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine in kidney transplant recipients (Recipients) compared with those in kidney donors (Donors) and healthy volunteers (HVs) and identify factors negatively associated with SARS-CoV-2 vaccine effectiveness in Recipients.

Basic procedures

We enrolled 378 Recipients who had no history of coronavirus disease 2019 (COVID-19) and no anti-S-IgG before the first vaccine and received a 2nd mRNA-based vaccine dose. Antibodies were detected using an immunoassay more than 4 weeks after the 2nd vaccine dose. Anti-S-IgG <0.8, ≥0.8–15, and ≥15 U/mL were considered negative, weak po

SUBMITTER: Sasaki H 

PROVIDER: S-EPMC9968606 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature