Ontology highlight
ABSTRACT:
SUBMITTER: Santos LD
PROVIDER: S-EPMC9968621 | biostudies-literature | 2023 Apr
REPOSITORIES: biostudies-literature
Santos Leonardo Duarte LD Antunes Krist Helen KH Cassão Gisele G Gonçalves João Ismael JI Abbadi Bruno Lopes BL Bizarro Cristiano Valim CV Basso Luiz Augusto LA Machado Pablo P de Souza Ana Paula D APD Porto Bárbara Nery BN
International immunopharmacology 20230227
We analyzed the ability of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) itself and SARS-CoV-2-IgG immune complexes to trigger human monocyte necroptosis. SARS-CoV-2 was able to induce monocyte necroptosis dependently of MLKL activation. Necroptosis-associated proteins (RIPK1, RIPK3 and MLKL) were involved in SARS-CoV-2N1 gene expression in monocytes. SARS-CoV-2 immune complexes promoted monocyte necroptosis in a RIPK3- and MLKL-dependent manner, and Syk tyrosine kinase was necess ...[more]