Functional connectivity and gray matter deficits within the auditory attention circuit in first-episode psychosis

ABSTRACT:

Background

Selective attention deficits in first episode of psychosis (FEP) can be indexed by impaired attentional modulation of auditory M100. It is unknown if the pathophysiology underlying this deficit is restricted to auditory cortex or involves a distributed attention network. We examined the auditory attention network in FEP.

Methods

MEG was recorded from 27 FEP and 31 matched healthy controls (HC) while alternately ignoring or attending tones. A whole-brain analysis of MEG source activity during auditory M100 identified non-auditory areas with increased activity. Time-frequency activity and phase-amplitude coupling were examined in auditory cortex to identify the attentional executive carrier frequency. Attention networks were defined by phase-locking at the carrie

SUBMITTER:  

PROVIDER: S-EPMC9968732 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature