Multi-omics integration to identify the genetic expression and protein signature of dilated and ischemic cardiomyopathy.

ABSTRACT:

Introduction

Heart failure (HF) is a complex clinical syndrome leading to high morbidity. In this study, we aimed to identify the gene expression and protein signature of HF main causes, namely dilated cardiomyopathy (DCM) and ischemic cardiomyopathy (ICM).

Methods

Omics data were accessed through GEO repository for transcriptomic and PRIDE repository for proteomic datasets. Sets of differentially expressed genes and proteins comprising DCM (DiSig) and ICM (IsSig) signatures were analyzed by a multilayered bioinformatics approach. Enrichment analysis via the Gene Ontology was performed through the Metascape platform to explore biological pathways. Protein-protein interaction networks were analyzed via STRING db and Network Analyst.

Results

Intersection o

SUBMITTER: Portokallidou K 

PROVIDER: S-EPMC9968758 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature