Causal associations between site-specific cancer and diabetes risk: A two-sample Mendelian randomization study.

ABSTRACT:

Background

Both cancer and diabetes are complex chronic diseases that have high economic costs for society. The co-occurrence of these two diseases in people is already well known. The causal effects of diabetes on the development of several malignancies have been established, but the reverse causation of these two diseases (e.g., what type of cancer can cause T2D) has been less investigated.

Methods

Multiple Mendelian randomization (MR) methods, such as the inverse-variance weighted (IVW) method, weighted median method, MR-Egger, and MR pleiotropy residual sum and outlier test, were performed to evaluate the causal association of overall and eight site-specific cancers with diabetes risk using genome-wide association study summary data from different consortia, such as Finn

SUBMITTER: Xu R 

PROVIDER: S-EPMC9968794 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature