Resolving the mesoscopic missing link: Biophysical modeling of EEG from cortical columns in primates.

ABSTRACT: Event-related potentials (ERP) are among the most widely measured indices for studying human cognition. While their timing and magnitude provide valuable insights, their usefulness is limited by our understanding of their neural generators at the circuit level. Inverse source localization offers insights into such generators, but their solutions are not unique. To address this problem, scientists have assumed the source space generating such signals comprises a set of discrete equivalent current dipoles, representing the activity of small cortical regions. Based on this notion, theoretical studies have employed forward modeling of scalp potentials to understand how changes in circuit-level dynamics translate into macroscopic ERPs. However, experimental validation is lacking because it requ

SUBMITTER: Herrera B 

PROVIDER: S-EPMC9968827 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature