Current clinical trials with non-coding RNA-based therapeutics in malignant diseases: A systematic review.

ABSTRACT: This systematic review aimed to shed light on the trend of current clinical trials of non-coding RNA (ncRNA)-based therapeutics for malignant diseases. We conducted a database search for published literature and ongoing clinical trials using PubMed, clinicaltrials.gov, and University Medical Information Network (UMIN) clinical trial registry. To ensure that our review was based on up-to-date clinical trials, we limited our search to literature published within the last five years (January 2017-September 2022). Furthermore, due to the "clinical" nature of our review, we focused only on studies involving human participants. Among ncRNAs, microRNAs have been extensively explored in observational studies of malignant diseases as potential diagnostic markers and prognostic predictors, as well a

SUBMITTER: Ito M 

PROVIDER: S-EPMC9969060 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature