Systemic inflammatory markers in patients with polyneuropathies

ABSTRACT:

Introduction

In patients with peripheral neuropathies (PNP), neuropathic pain is present in 50% of the cases, independent of the etiology. The pathophysiology of pain is poorly understood, and inflammatory processes have been found to be involved in neuro-degeneration, -regeneration and pain. While previous studies have found a local upregulation of inflammatory mediators in patients with PNP, there is a high variability described in the cytokines present systemically in sera and cerebrospinal fluid (CSF). We hypothesized that the development of PNP and neuropathic pain is associated with enhanced systemic inflammation.

Methods

To test our hypothesis, we performed a comprehensive analysis of the protein, lipid and gene expression of different pro- and anti-inflammatory ma

SUBMITTER: Garcia-Fernandez P 

PROVIDER: S-EPMC9969086 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature