Association of NOS1AP genetic variants with QT interval duration in families from the Diabetes Heart Study.

ABSTRACT:

Objectives

Prolongation of the electrocardiographic QT interval is a risk factor for sudden cardiac death (SCD). Diabetic individuals are at increased risk for prolonged QT interval and SCD. We sought to replicate the finding that genetic variants in the nitric oxide synthase 1 adaptor protein (NOS1AP) gene are associated with QT interval duration in a type 2 diabetes-enriched sample of European ancestry.

Research design and methods

Two single nucleotide polymorphisms (SNPs) in NOS1AP were genotyped in 624 European Americans and 127 African Americans from 400 pedigrees enriched for type 2 diabetes. An additive genetic model was tested for each SNP in ancestry-specific analyses in the total sample and the diabetic subset (European Americans, n = 514; African Americans, n = 11

SUBMITTER: Lehtinen AB 

PROVIDER: S-EPMC9969196 | biostudies-literature | 2008 Apr

REPOSITORIES: biostudies-literature