Protective effects of pentoxifylline against chlorine-induced acute lung injury in rats.

ABSTRACT:

Objective

Chlorine is a chemical threat agent that can be harmful to humans. Inhalation of high levels of chlorine can lead to acute lung injury (ALI). Currently, there is no satisfactory treatment, and effective antidote is urgently needed. Pentoxifylline (PTX), a methylxanthine derivative and nonspecific phosphodiesterase inhibitor, is widely used for the treatment of vascular disorders. The present study was aimed to investigate the inhibitory effects of PTX on chlorine-induced ALI in rats.

Methods

Adult male Sprague-Dawley rats were exposed to 400 ppm Cl₂ for 5 min. The histopathological examination was carried out and intracellular reactive oxygen species (ROS) levels were measured by the confocal laser scanning system. Subsequently, to evaluate the effect of

SUBMITTER: Liu MM 

PROVIDER: S-EPMC9969370 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature