Determination of binding affinity of tunicamycin with SARS-CoV-2 proteins: Proteinase, protease, nsp2, nsp9, ORF3a, ORF7a, ORF8, ORF9b, envelope and RBD of spike glycoprotein Determinacion de la afinidad de union de la tunicamicina con las proteinas del SARS-CoV-2: proteinasa, proteasa, nsp2, nsp9, ORF3a, ORF7a, ORF8, ORF9b, envolvente y RBD de la glicoproteina Spike

ABSTRACT:

Introduction

Despite the availability of several COVID-19 vaccines, the incidence of infections remains a serious issue. Tunicamycin (TM), an antibiotic, inhibited tumor growth, reduced coronavirus envelope glycoprotein subunit 2 synthesis, and decreased N-linked glycosylation of coronavirus glycoproteins.

Objectives

Our study aimed to determine how tunicamycin interacts with certain coronavirus proteins (proteinase, protease, nsp9, ORF7a, ORF3a, ORF9b, ORF8, envelope protein, nsp2, and RBD of spike glycoprotein). Methods: Several types of chemo and bioinformatics tools were used to achieve the aim of the study. As a result, virion's effectiveness may be impaired.

Results

TM can bind to viral proteins with various degrees of affinity. The proteinase had the highe

SUBMITTER:  

PROVIDER: S-EPMC9969538 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature