Construction of a radiogenomic association map of pancreatic ductal adenocarcinoma.

ABSTRACT:

Background

Pancreatic adenocarcinoma (PDAC) persists as a malignancy with high morbidity and mortality that can benefit from new means to characterize and detect these tumors, such as radiogenomics. In order to address this gap in the literature, constructed a transcriptomic-CT radiogenomic (RG) map for PDAC.

Methods

In this Institutional Review Board approved study, a cohort of subjects (n = 50) with gene expression profile data paired with histopathologically confirmed resectable or borderline resectable PDAC were identified. Studies with pre-operative contrast-enhanced CT images were independently assessed for a set of 88 predefined imaging features. Microarray gene expression profiling was then carried out on the histopathologically confirmed pancreatic adenocarcinomas a

SUBMITTER: Jamshidi N 

PROVIDER: S-EPMC9969670 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature