Association between Cystic Fibrosis exacerbations, lung function, T2 inflammation and microbiological colonization.

ABSTRACT:

Background

The Cystic Fibrosis Foundation Patient Registry (CFFPR) reports a high prevalence of asthma (34.6%) in people with Cystic Fibrosis (PwCF). While our current understanding of this relationship is limited, a type 2 inflammatory (T2) phenotype has often been identified in CF patients.

Research question

This study aimed to evaluate the relationship between the eosinophilic CF T2 inflammatory phenotype and CF-related pulmonary outcomes and microbiological data.

Study design and methods

We conducted a retrospective chart review of adult patients with CF (18 and older; n = 93) receiving their care at University of Virginia Medical Center adult program from January, 2013 through December, 2018. Data collected included demographic data, CFTR (CF transmembrane conduc

SUBMITTER: Albon D 

PROVIDER: S-EPMC9969710 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature