Durable virological response and functional cure of chronic hepatitis D after long-term peginterferon therapy.

ABSTRACT:

Background

Hepatitis delta virus (HDV) infection is the most aggressive form of chronic viral hepatitis. Response rates to therapy with 1- to 2-year courses of pegylated interferon alpha (peginterferon) treatment are suboptimal.

Aims

To evaluate the long-term outcomes of patients with chronic hepatitis D after an extended course of peginterferon.

Methods

Patients were followed after completion of trial NCT00023322 and classified based on virological response defined as loss of detectable serum HDV RNA at last follow-up. During extended follow-up, survival and liver-related events were recorded.

Results

All 12 patients who received more than 6 months of peginterferon in the original study were included in this analysis. The cohort was mostly white (83%) and male

SUBMITTER: Hercun J 

PROVIDER: S-EPMC9969742 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature