Population Pharmacokinetics of Piperacillin/Tazobactam Across the Adult Lifespan.

ABSTRACT:

Background and objective

Piperacillin/tazobactam is one of the most frequently used antimicrobials in older adults. Using an opportunistic study design, we evaluated the pharmacokinetics of piperacillin/tazobactam as a probe drug to evaluate changes in antibacterial drug exposure and dosing requirements, including in older adults.

Methods

A total of 121 adult patients were included. The population pharmacokinetic models that best characterized the observed plasma concentrations of piperacillin and tazobactam were one-compartment structural models with zero-order input and linear elimination.

Results

Among all potential covariates, estimated creatinine clearance had the most substantial impact on the elimination clearance for both piperacillin and tazobactam. After acc

SUBMITTER: Hemmersbach-Miller M 

PROVIDER: S-EPMC9969806 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature