A novel strategy for dynamic modeling of genome-scale interaction networks.

ABSTRACT:

Motivation

The recent availability of omics data allows the construction of holistic maps of interactions between numerous role-playing biomolecules. However, these networks are often static, ignoring the dynamic behavior of biological processes. On the other hand, dynamic models are commonly constructed on small scales. Hence, the construction of large-scale dynamic models that can quantitatively predict the time-course cellular behaviors remains a big challenge.

Results

In this study, a pipeline is proposed for the automatic construction of large-scale dynamic models. The pipeline uses a list of biomolecules and their time-course trajectories in a given phenomenon as input. First, the interaction network of the biomolecules is constructed. To state the underlying molecular

SUBMITTER: Borzou P 

PROVIDER: S-EPMC9969830 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature