Transformable amyloid-beta mimetic peptide amphiphiles for lysosomal disruption in non-small cell lung cancer.

ABSTRACT: Non-small cell lung cancer (NSCLC) is the largest contributor to cancer mortality in the United States. Traditional chemotherapies are toxic and prone to the development of drug-resistance. Recently, several drug candidates were shown to induce lysosomal membrane permeabilization (LMP) in aggressive cancers. This has led to increased interest in lysosome dysregulation as a therapeutic target. However, approaches are needed to overcome two limitations of current lysosomal inhibitors: low specificity and potency. Here, we report the development of a transformable nanomaterial which is triggered to induce LMP of lysosomes in NSCLC. The nanomaterial consists of peptide amphiphiles, which self-assemble into nanoparticles, colocalize with the lysosome, and change conformation to nanofibrils due

SUBMITTER: Baehr CM 

PROVIDER: S-EPMC9969961 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature