Dataset Information

Thyroxine changes in COVID-19 pandemic: A systematic review and meta-analysis.

ABSTRACT:

Objective

COVID-19 infection may affect thyroid function. However, changes in thyroid function in COVID-19 patients have not been well described. This systematic review and meta-analysis assess thyroxine levels in COVID-19 patients, compared with non-COVID-19 pneumonia and healthy cohorts during the COVID-19 epidemic.

Methods

A search was performed in English and Chinese databases from inception to August 1, 2022. The primary analysis assessed thyroid function in COVID-19 patients, comparing non-COVID-19 pneumonia and healthy cohorts. Secondary outcomes included different severity and prognoses of COVID-19 patients.

Results

A total of 5873 patients were enrolled in the study. The pooled estimates of TSH and FT3 were significantly lower in patients with COVID-19 and non-COVID-19 pneumonia than in the healthy cohort (P < 0.001), whereas FT4 were significantly higher (P < 0.001). Patients with the non-severe COVID-19 showed significant higher in TSH levels than the severe (I² = 89.9%, P = 0.002) and FT3 (I² = 91.9%, P < 0.001). Standard mean differences (SMD) of TSH, FT3, and FT4 levels of survivors and non-survivors were 0.29 (P= 0.006), 1.11 (P < 0.001), and 0.22 (P < 0.001). For ICU patients, the survivors had significantly higher FT4 (SMD=0.47, P=0.003) and FT3 (SMD=0.51, P=0.001) than non-survivors.

Conclusions

Compared with the healthy cohort, COVID-19 patients showed decreased TSH and FT3 and increased FT4, similar to non-COVID-19 pneumonia. Thyroid function changes were related to the severity of COVID-19. Thyroxine levels have clinical significance for prognosis evaluation, especially FT3.

SUBMITTER: Li Z

PROVIDER: S-EPMC9969987 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Thyroxine changes in COVID-19 pandemic: A systematic review and meta-analysis.

Li Ziqi Z Hou Pengwei P Mu Shuwen S Wang Renzhi R Miao Hui H Feng Ming M Wang He H Zhang Wentai W Chen Yihao Y Feng Tianshun T Wang Shousen S Fang Yi Y

Frontiers in endocrinology 20230213

<h4>Objective</h4>COVID-19 infection may affect thyroid function. However, changes in thyroid function in COVID-19 patients have not been well described. This systematic review and meta-analysis assess thyroxine levels in COVID-19 patients, compared with non-COVID-19 pneumonia and healthy cohorts during the COVID-19 epidemic.<h4>Methods</h4>A search was performed in English and Chinese databases from inception to August 1, 2022. The primary analysis assessed thyroid function in COVID-19 patients ...[more]

PMID: 36860369

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Dataset Information

Thyroxine changes in COVID-19 pandemic: A systematic review and meta-analysis.

Objective

Methods

Results

Conclusions

Publications

Thyroxine changes in COVID-19 pandemic: A systematic review and meta-analysis.

Similar Datasets

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