Longitudinal Signal-to-Noise Ratio of Perimetry at Different Severities of Glaucoma.

ABSTRACT:

Purpose

Automated perimetry is relied on for functional assessment of patients with glaucoma, but questions remain about its effective dynamic range and its utility for quantifying rates of progression at different stages of the disease. This study aims to identify the bounds within which estimates of rate are most reliable.

Methods

Pointwise longitudinal signal-to-noise ratios (LSNR), defined as the rate of change divided by the standard error of the trend line, were calculated for 542 eyes of 273 patients with glaucoma/suspects. The relations between the mean sensitivity within each series and lower percentiles of the distribution of LSNRs (representing progressing series) were analyzed by quantile regression, with 95% confidence intervals derived by bootstrapping.

Resu

SUBMITTER: Gardiner SK 

PROVIDER: S-EPMC9970001 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature