Relationship between NAFLD and coronary artery disease: A Mendelian randomization study.

ABSTRACT:

Background and aims

There is an ongoing debate on whether NAFLD is an active contributor or an innocent bystander in the pathogenesis of coronary artery disease (CAD). The aim of the present study was to assess the causal relationship between NAFLD and CAD.

Approach and results

We performed two-sample Mendelian randomization (MR) analyses using summary-level data to assess the association between genetically predicted NAFLD (i.e., chronically elevated serum alanine aminotransferase levels [cALT], imaging-based and biopsy-confirmed NAFLD) and risk of CAD. Analyses were repeated after exclusion of NAFLD susceptibility genes that are associated with impaired VLDL secretion.Inverse-variance weighted MR analyses showed a statistically significant association between genetically p

SUBMITTER: Ren Z 

PROVIDER: S-EPMC9970021 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature