Hippocampal, basal ganglia and olfactory connectivity contribute to cognitive impairments in Parkinson's disease.

ABSTRACT: Cognitive impairment is increasingly recognized as a characteristic feature of Parkinson's disease (PD), yet relatively little is known about its underlying neurobiology. Previous investigations suggest that dementia in PD is associated with subcortical atrophy, but similar studies in PD with mild cognitive impairment have been mixed. Variability in cognitive phenotypes and diversity of PD symptoms suggest that a common neuropathological origin results in a multitude of impacts within the brain. These direct and indirect impacts of disease pathology can be investigated using network analysis. Functional connectivity, for instance, may be more sensitive than atrophy to decline in specific cognitive domains in the PD population. Fifty-eight participants with PD underwent a neuropsychological

SUBMITTER: Wylie KP 

PROVIDER: S-EPMC9970048 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature