The metabolic profile of waist to hip ratio-A multi-cohort study.

ABSTRACT:

Background

The genetic background of general obesity and fat distribution is different, pointing to separate underlying physiology. Here, we searched for metabolites and lipoprotein particles associated with fat distribution, measured as waist/hip ratio adjusted for fat mass (WHRadjfatmass), and general adiposity measured as percentage fat mass.

Method

The sex-stratified association of 791 metabolites detected by liquid chromatography-mass spectrometry (LC-MS) and 91 lipoprotein particles measured by nuclear magnetic spectroscopy (NMR) with WHRadjfatmass and fat mass were assessed using three population-based cohorts: EpiHealth (n = 2350) as discovery cohort, with PIVUS (n = 603) and POEM (n = 502) as replication cohorts.

Results

Of the 193 LC-MS-metabolites being ass

SUBMITTER: Lind L 

PROVIDER: S-EPMC9970070 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature