In vivo serotonin 1A receptor hippocampal binding potential in depression and reported childhood adversity.

ABSTRACT:

Background

Reported childhood adversity (CA) is associated with development of depression in adulthood and predicts a more severe course of illness. Although elevated serotonin 1A receptor (5-HT_1AR) binding potential, especially in the raphe nuclei, has been shown to be a trait associated with major depression, we did not replicate this finding in an independent sample using the partial agonist positron emission tomography tracer [¹¹C]CUMI-101. Evidence suggests that CA can induce long-lasting changes in expression of 5-HT_1AR, and thus, a history of CA may explain the disparate findings.

Methods

Following up on our initial report, 28 unmedicated participants in a current depressive episode (bipolar n = 16, unipolar n = 12) and 1

SUBMITTER: Bartlett EA 

PROVIDER: S-EPMC9970152 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature