Baicalein attenuates bleomycin-induced lung fibroblast senescence and lung fibrosis through restoration of Sirt3 expression.

ABSTRACT:

Context

Fibroblast senescence was reported to contribute to the pathological development of idiopathic pulmonary fibrosis (IPF), and baicalein is reported to attenuate IPF.

Objective

This study explores whether baicalein attenuates lung fibrosis by regulating lung fibroblast senescence.

Materials and methods

Institute of Cancer Research (ICR) mice were randomly assigned to control, bleomycin (BLM), baicalein and BLM + baicalein groups. Lung fibrosis was established by a single intratracheal dose of BLM (3 mg/kg). The baicalein group received baicalein orally (100 mg/kg/day). Sirtuin 3 (Sirt3) siRNA (50 μg) was injected through the tail vein once a week for 2 weeks to explore its effect on the anti-pulmonary fibrosis of baicalein.

Results

BLM-treated mice exhibi

SUBMITTER: Ji-Hong Y 

PROVIDER: S-EPMC9970214 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature