Metformin use history and genome-wide DNA methylation profile: potential molecular mechanism for aging and longevity.

ABSTRACT:

Background

Metformin, a commonly prescribed anti-diabetic medication, has repeatedly been shown to hinder aging in pre-clinical models and to be associated with lower mortality for humans. It is, however, not well understood how metformin can potentially prolong lifespan from a biological standpoint. We hypothesized that metformin's potential mechanism of action for longevity is through its epigenetic modifications.

Methods

To test our hypothesis, we conducted a post-hoc analysis of available genome-wide DNA methylation (DNAm) data obtained from whole blood collected from inpatients with and without a history of metformin use. We assessed the methylation profile of 171 patients (first run) and only among 63 diabetic patients (second run) and compared the DNAm rates between m

SUBMITTER: Marra PS 

PROVIDER: S-EPMC9970305 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature