The pan-cancer analysis identified DIAPH3 as a diagnostic biomarker of clinical cancer.

ABSTRACT:

Objective

This study aimed to determine prognostic biomarkers of cervical cancer by pan-cancer analysis.

Materials and methods

Common differentially expressed genes in Gene Expression Omnibus and The Cancer Genome Atlas (TCGA) database were demonstrated using R software analysis, and these genes were enriched by the Kyoto Encyclopedia of Genes and Genomes and Gene Ontology. Genes with prognostic value were identified by least absolute contraction and selection regression, Cox regression, and survival analysis, and pan-cancer analysis was conducted using the Tumor Immune Estimation Resource database and TCGA database. Western blot, qRT-PCR, and immunohistochemistry were used to preliminarily verify its expression in cervical cancer (S1).

Results

The prognostic marker D

SUBMITTER: Chen X 

PROVIDER: S-EPMC9970313 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature