Epigenetic age and lung cancer risk in the CLUE II prospective cohort study.

ABSTRACT:

Background

Epigenetic age, a robust marker of biological aging, has been associated with obesity, low-grade inflammation and metabolic diseases. However, few studies have examined associations between different epigenetic age measures and risk of lung cancer, despite great interest in finding biomarkers to assist in risk stratification for lung cancer screening.

Methods

A nested case-control study of lung cancer from the CLUE II cohort study was conducted using incidence density sampling with 1:1 matching of controls to lung cancer cases (n = 208 matched pairs). Prediagnostic blood samples were collected in 1989 (CLUE II study baseline) and stored at -70°C. DNA was extracted from buffy coat and DNA methylation levels were measured using Illumina MethylationEPIC BeadCh

SUBMITTER: Michaud DS 

PROVIDER: S-EPMC9970317 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature