Impaired dendritic spike generation in the Fragile X prefrontal cortex is due to loss of dendritic sodium channels.

ABSTRACT: Patients with Fragile X syndrome, the leading monogenetic cause of autism, suffer from impairments related to the prefrontal cortex, including working memory and attention. Synaptic inputs to the distal dendrites of layer 5 pyramidal neurons in the prefrontal cortex have a weak influence on the somatic membrane potential. To overcome this filtering, distal inputs are transformed into local dendritic Na⁺ spikes, which propagate to the soma and trigger action potential output. Layer 5 extratelencephalic (ET) prefrontal cortex (PFC) neurons project to the brainstem and various thalamic nuclei and are therefore well positioned to integrate task-relevant sensory signals and guide motor actions. We used current clamp and outside-out patch clamp recording to investigate dendritic spike

SUBMITTER: Brandalise F 

PROVIDER: S-EPMC9970745 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature