3D-Printed Tumor Phantoms for Assessment of In Vivo Fluorescence Imaging Analysis Methods.

ABSTRACT:

Purpose

Interventional fluorescence imaging is increasingly being utilized to quantify cancer biomarkers in both clinical and preclinical models, yet absolute quantification is complicated by many factors. The use of optical phantoms has been suggested by multiple professional organizations for quantitative performance assessment of fluorescence guidance imaging systems. This concept can be further extended to provide standardized tools to compare and assess image analysis metrics.

Procedures

3D-printed fluorescence phantoms based on solid tumor models were developed with representative bio-mimicking optical properties. Phantoms were produced with discrete tumors embedded with an NIR fluorophore of fixed concentration and either zero or 3% non-specific fluorophore in the sur

SUBMITTER: LaRochelle EPM 

PROVIDER: S-EPMC9970939 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature