DNA methylation in cocaine use disorder-An epigenome-wide approach in the human prefrontal cortex.

ABSTRACT:

Background

Cocaine use disorder (CUD) is characterized by a loss of control over cocaine intake and is associated with structural, functional, and molecular alterations in the human brain. At the molecular level, epigenetic alterations are hypothesized to contribute to the higher-level functional and structural brain changes observed in CUD. Most evidence of cocaine-associated epigenetic changes comes from animal studies while only a few studies have been performed using human tissue.

Methods

We investigated epigenome-wide DNA methylation (DNAm) signatures of CUD in human post-mortem brain tissue of Brodmann area 9 (BA9). A total of N = 42 BA9 brain samples were obtained from N = 21 individuals with CUD and N = 21 individuals without a CUD diagnosis. We

SUBMITTER: Poisel E 

PROVIDER: S-EPMC9970996 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature