Wnt pathway inhibitors are upregulated in XLH dental pulp cells in response to odontogenic differentiation.

ABSTRACT: X-linked hypophosphatemia (XLH) represents the most common form of familial hypophosphatemia. Although significant advances have been made in the treatment of bone pathology, patients undergoing therapy continue to experience significantly decreased oral health-related quality of life. The following study addresses this persistent oral disease by further investigating the effect of DMP1 expression on the differentiation of XLH dental pulp cells. Dental pulp cells were isolated from the third molars of XLH and healthy controls and stable transduction of full-length human DMP1 were achieved. RNA sequencing was performed to evaluate the genetic changes following the induction of odontogenic differentiation. RNAseq data shows the upregulation of inhibitors of the canonical Wnt pathway in XLH c

SUBMITTER: Guirado E 

PROVIDER: S-EPMC9971210 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature