Ecological shifts of salivary microbiota associated with metabolic-associated fatty liver disease.

ABSTRACT:

Introduction

Metabolic-associated fatty liver disease (MAFLD) is the most common chronic liver disease related to metabolic syndrome. However, ecological shifts in the saliva microbiome in patients with MAFLD remain unknown. This study aimed to investigate the changes to the salivary microbial community in patients with MAFLD and explore the potential function of microbiota.

Methods

Salivary microbiomes from ten MAFLD patients and ten healthy participants were analyzed by 16S rRNA amplicon sequencing and bioinformatics analysis. Body composition, plasma enzymes, hormones, and blood lipid profiles were assessed with physical examinations and laboratory tests.

Results

The salivary microbiome of MAFLD patients was characterized by increased α-diversity and distinct β-div

SUBMITTER: Wang M 

PROVIDER: S-EPMC9971218 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature