Tissue-resident, memory CD8⁺ T cells are effective in clearing intestinal Eimeria falciformis reinfection in mice.

ABSTRACT: Eimeria, a cousin of malarial parasites, causes coccidiosis that results in huge losses in the poultry industry. Although live coccidiosis vaccines have been developed and used widely for the successful control of the disease, the mechanism underlying protective immunity remains largely unknown. Using Eimeria falciformis as a model parasite, we observed that tissue-resident memory CD8⁺ T (Trm) cells accumulated in cecal lamina propria following E. falciformis infection in mice, especially after reinfection. In convalescent mice challenged with a second infection, E. falciformis burden diminished within 48-72 h. Deep-sequencing revealed that CD8⁺ Trm cells were characterized by rapid up-regulation of effector genes encoding pro-inflammatory

SUBMITTER: Shi F 

PROVIDER: S-EPMC9971219 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature